2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
HJC 0350
CAS: 885434-70-8
Molecular Formula: C15H19NO2S
2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole - Names and Identifiers
2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole - Physico-chemical Properties
| Molecular Formula | C15H19NO2S |
| Molar Mass | 277.38 |
| Density | 1.13±0.1 g/cm3(Predicted) |
| Boling Point | 434.6±55.0 °C(Predicted) |
| Solubility | DMSO: soluble5mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| pKa | -6.94±0.70(Predicted) |
| Storage Condition | room temp |
| In vitro study | HJC0350 selectively blocks cAMP-induced EPAC2 activation, but does not inhibit cAMP-mediated PKA activation. In HEK293/EPAC2-FL cells, HJC0350 also inhibited 007-am-mediated activation of EPAC2 in cells. |
2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole - Risk and Safety
| WGK Germany | 3 |
2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.605 ml | 18.026 ml | 36.052 ml |
| 5 mM | 0.721 ml | 3.605 ml | 7.21 ml |
| 10 mM | 0.361 ml | 1.803 ml | 3.605 ml |
| 5 mM | 0.072 ml | 0.361 ml | 0.721 ml |
Last Update：2024-01-02 23:10:35
2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole - Reference Information
| biological activity | HJC0350 is a potent and selective inhibitor of EPAC2 with an IC50 of 0.3 μm and no inhibition of epac1. |
| Target | IC50: 0.3 µm (EPAC2) |
Last Update：2024-04-09 18:58:34
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Product Name: HJC 0350 Visit Supplier Webpage Request for quotationCAS: 885434-70-8
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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